Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant

This research was done to formulate and assess the sustained release property of metformin tablets prepared from microcapsules produced by ionic gelation technique using Sida acuta gum or sodium carboxymethylcellulose as retardant. isopropyl alcohol precipitation filtrate obtained distilled water maceration powdered dried leaves. Metformin compatibility determined FTIR. were alginate alone with either The evaluated for % yield flow properties. size surface morphology scanning electron microscopy. direct compression technique. hardness, friability in vitro dissolution. There no major incompatibility between gum. have excellent micrometer range. They rough surfaces. ranged 0.4-1.6% while hardness 3.82-11.17 Kgf. formulations M2 failed both test. About 44.5-47.1% released tablet after 6 h 86.0-100% 10 h. All showed ability.
 Keywords: Microcapsules, metformin, gum, release,